Diagnostic Performance of Plasma P‐tau217, NfL, and GFAP for Predicting Alzheimer’s Disease Neuropathology Across Diverse Neurodegenerative Syndromes
Hanna Cho, Mark E Sanderson‐Cimino, Jonathan Tablante, Fattin Wekselman, Lea T Grinberg, Hilary W Heuer, Argentina Lario Lago, Peter A Ljubenkov, Julio C Rojas, William W Seeley, Salvatore Spina, Adam M Staffaroni, Gallen Triana‐Baltzer, Hartmuth C Kolb, Renaud La Joie, Gil D Rabinovici, Adam L Boxe · 2025
Read Diagnostic Performance of Plasma P‐tau217, NfL, and GFAP for Predicting Alzheimer’s Disease Neuropathology Across Diverse Neurodegenerative Syndromes by Hanna Cho, Mark E Sanderson‐Cimino, Jonathan Tablante, Fattin Wekselman, Lea T Grinberg, Hilary W Heuer, Argentina Lario Lago, Peter A Ljubenkov, Julio C Rojas, William W Seeley, Salvatore Spina, Adam M Staffaroni, Gallen Triana‐Baltzer, Hartmuth C Kolb, Renaud La Joie, Gil D Rabinovici, Adam L Boxe (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715677.txt.
Description
Hanna Cho and a large team test whether three blood markers can flag Alzheimer's pathology across many brain diseases. New Alzheimer's drugs make early, exact detection vital. Blood tests are cheap, but their worth in mixed clinics was unclear. Their 2025 study uses 349 people whose brains were checked after death at one center. Blood drawn in life was tested for a tau marker and two damage markers.
The donors carried twelve different clinical syndromes, from Alzheimer's to Lewy body disease, plus healthy controls. Exam at autopsy fixed who truly had Alzheimer's changes. That ground truth lets the team grade each marker fairly. Mixed pathology is the hard case the study targets. The design shows how blood tests might sort real Alzheimer's from its mimics.
Catalog record
| CREATOR | Hanna Cho, Mark E Sanderson‐Cimino, Jonathan Tablante, Fattin Wekselman, Lea T Grinberg, Hilary W Heuer, Argentina Lario Lago, Peter A Ljubenkov, Julio C Rojas, William W Seeley, Salvatore Spina, Adam M Staffaroni, Gallen Triana‐Baltzer, Hartmuth C Kolb, Renaud La Joie, Gil D Rabinovici, Adam L Boxe |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |