Distinct dementia atrophy progression patterns associated with different epidemiological risk factors
Alexander David Shapson‐Coe, Sheena Waters, Neil P Oxtoby, Charles R Marshall · 2025
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Description
Dementia in the wild is usually a mix of diseases, not the pure cases of clinic studies, so Shapson-Coe and co-authors let the data sort itself. They run a subtype-and-stage algorithm on brain scans from UK Biobank members with dementia, including many scanned before diagnosis. Two progression patterns emerge from the shrinkage maps.
One follows the classic Alzheimer's route through the memory centers and matches most cases. The other, rarer pattern starts in the cerebellum and deep structures. It looks like a blend of Alzheimer's and vessel disease. Its members carried higher body mass and more white matter damage, with no difference in Alzheimer's genetic risk. The authors say the split may clarify the earliest stages.
Catalog record
| CREATOR | Alexander David Shapson‐Coe, Sheena Waters, Neil P Oxtoby, Charles R Marshall |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |