The impact of polygenic cardiovascular risk on Alzheimer’s‐like brain changes
Sarah‐Alexis Lenhoff, Frederick A Page, Joseph Nowell, Paul Edison · 2025
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Description
Sarah-Alexis Lenhoff and co-authors test whether inherited heart risk tracks with Alzheimer-like brain change, in a 2025 study. Heart and vessel risk has long been tied to dementia. Genes offer a clean way to test that link without the noise of daily habits.
The team used the UK Biobank resource, with near thirty thousand people. A combined gene score for heart risk was set against brain scan measures. Higher gene risk went with more deep white matter damage and less total grey matter. One tract near the memory region also showed wear. Blood flow showed no link. The results support a gene level path from heart risk to brain change.
Catalog record
| CREATOR | Sarah‐Alexis Lenhoff, Frederick A Page, Joseph Nowell, Paul Edison |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |