High‐performance plasma proteomic biomarker candidates in early Alzheimer's disease
Yuhan Xie, Hui Sun, Fang Liu, Yaonan Zheng, Mang Zhang, Xin Ma, Xin Yu, nan zhang, chaolan huang, Huali Wang · 2025
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Description
Yuhan Xie and co-authors search blood plasma in 2025 for protein markers of early Alzheimer disease. A blood test for this stage would be far easier than brain scans or spinal fluid tests. The team compared plasma from fifty patients with early, amyloid positive disease and forty-nine healthy controls using mass based protein measures.
Network analysis linked protein levels to thinking scores and to amyloid load seen on brain scans. From more than a thousand proteins that differed in disease, a panel of twenty-two was picked as the best match for the disease profile. Those proteins touch amyloid making, breakdown, and immune work. The panel split patients from controls with high accuracy in this sample, marking candidates that now need testing in larger and more varied groups.
Catalog record
| CREATOR | Yuhan Xie, Hui Sun, Fang Liu, Yaonan Zheng, Mang Zhang, Xin Ma, Xin Yu, nan zhang, chaolan huang, Huali Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |