Inflammatory Architecture of Frailty in the Realm of Alzheimer's Disease and Related Dementias
Jiachen Chen, Margaret F Doyle, Yumeng Cao, Ahmed Ragab, Joanne M Murabito, Kathryn L. Lunetta · 2025
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Description
Jiachen Chen and co-authors chart the inflammation behind frailty and dementia risk in this 2025 study. Frailty, the slow loss of strength and reserve with age, raises the odds of Alzheimer's disease and related dementias. Which immune signals drive that link was unclear.
The team studied 741 Framingham participants, dementia-free at entry and followed about sixteen years. Blood samples carried 209 inflammation markers, from immune cells to signaling proteins. Half the group built a frailty signature; the other half tested it. The validated pattern was then checked against who developed dementia. The work may yield blood tests that flag risk while prevention still helps.
Catalog record
| CREATOR | Jiachen Chen, Margaret F Doyle, Yumeng Cao, Ahmed Ragab, Joanne M Murabito, Kathryn L. Lunetta |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |