Neighborhood disadvantage and ADRD pathology assessed with plasma biomarkers
Samriddhi Dube, W Ryan Powell, William R Buckingham, Kao Lee Yang, Sterling C Johnson, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Amy JH Kind, Barbara B Bendlin · 2025
Read Neighborhood disadvantage and ADRD pathology assessed with plasma biomarkers by Samriddhi Dube, W Ryan Powell, William R Buckingham, Kao Lee Yang, Sterling C Johnson, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Amy JH Kind, Barbara B Bendlin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715616.txt.
Description
Samriddhi Dube and co-authors ask whether living in a disadvantaged neighborhood leaves a mark on blood biomarkers of brain harm. Past work tied poor neighborhoods to more pathology at autopsy and on brain scans. Blood markers now let researchers test the link widely. Their 2025 study uses a Wisconsin registry of adults at risk for Alzheimer's disease, with neighborhoods scored by a state deprivation ranking.
The study held 371 adults and 1,095 blood measurements over time. Living in the most disadvantaged fifth of neighborhoods went with higher blood levels of a support-cell protein, GFAP. That protein has been tied to amyloid buildup and inflammation in the brain. Four other markers — three tau forms and a nerve fiber marker — showed no clear link. The team says the study may have been too small to catch weak links. More work should trace how place gets into the body.
Catalog record
| CREATOR | Samriddhi Dube, W Ryan Powell, William R Buckingham, Kao Lee Yang, Sterling C Johnson, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Amy JH Kind, Barbara B Bendlin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |