Recombinant zoster vaccine and reduced risk of dementia: matched‐cohort study using large‐scale electronic health records and machine learning methodology
Patrick Schwab, Robyn Widenmaier, Halima Tahrat, Maria Littmann, Bruno Anspach, Carolyn Buser‐Doepner, Andreas Georgiou, Max Horn, Sanjay Kumar, Vitaly Polisky, Aleksei Triastcyn, Cornelia M Van Duijn, Pascal Geldsetzer · 2025
Read Recombinant zoster vaccine and reduced risk of dementia: matched‐cohort study using large‐scale electronic health records and machine learning methodology by Patrick Schwab, Robyn Widenmaier, Halima Tahrat, Maria Littmann, Bruno Anspach, Carolyn Buser‐Doepner, Andreas Georgiou, Max Horn, Sanjay Kumar, Vitaly Polisky, Aleksei Triastcyn, Cornelia M Van Duijn, Pascal Geldsetzer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715525.txt.
Description
Patrick Schwab and a large team of co-authors published a 2025 study on whether the shingles vaccine is linked to lower dementia risk. Earlier work tied the older live shingles vaccine to fewer dementia diagnoses. The newer recombinant vaccine is now standard, and the team asked whether it shows the same link.
Using a large United States health records database, they formed matched groups of adults aged fifty and older. Recipients of the recombinant vaccine were compared with people who got a pneumonia vaccine, a control choice meant to reduce bias from health seeking behavior. Machine learning methods helped balance the groups. The study window covered records from 2007 to 2023. A confirmed link would raise the stakes of shingles vaccination beyond rash prevention.
Catalog record
| CREATOR | Patrick Schwab, Robyn Widenmaier, Halima Tahrat, Maria Littmann, Bruno Anspach, Carolyn Buser‐Doepner, Andreas Georgiou, Max Horn, Sanjay Kumar, Vitaly Polisky, Aleksei Triastcyn, Cornelia M Van Duijn, Pascal Geldsetzer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |