Mid‐ to late‐life changes in blood‐based biomarkers of Alzheimer’s disease pathology and neurodegeneration and associations with brain amyloid deposition: The ARIC‐PET Study
James Russell Pike, Yifei Lu, Jinyu Chen, Keenan A Walker, Kevin J Sullivan, Michael E Griswold, Bharat Thyagarajan, Michelle M Mielke, Pamela L Lutsey, Dean F Wong, David S Knopman, A Richey Sharrett, Josef Coresh, Thomas H Mosley, Rebecca F Gottesman, Priya Palta · 2025
Read Mid‐ to late‐life changes in blood‐based biomarkers of Alzheimer’s disease pathology and neurodegeneration and associations with brain amyloid deposition: The ARIC‐PET Study by James Russell Pike, Yifei Lu, Jinyu Chen, Keenan A Walker, Kevin J Sullivan, Michael E Griswold, Bharat Thyagarajan, Michelle M Mielke, Pamela L Lutsey, Dean F Wong, David S Knopman, A Richey Sharrett, Josef Coresh, Thomas H Mosley, Rebecca F Gottesman, Priya Palta (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715491.txt.
Description
James Russell Pike and co-authors follow Alzheimer blood markers across decades of life in a 2025 study. Simple blood tests promise a cheap, gentle way to detect the disease's changes long before memory fails. What is unclear is how those markers move from midlife onward, and how well they predict the amyloid plaques seen on brain scans.
The team drew on a long-running community study of heart and brain health. About three hundred dementia-free participants had MRI and amyloid scans in 2014 and 2015, with blood markers tracked over time. Seeing when blood signals turn, and in whom, could shape screening plans for whole populations.
Catalog record
| CREATOR | James Russell Pike, Yifei Lu, Jinyu Chen, Keenan A Walker, Kevin J Sullivan, Michael E Griswold, Bharat Thyagarajan, Michelle M Mielke, Pamela L Lutsey, Dean F Wong, David S Knopman, A Richey Sharrett, Josef Coresh, Thomas H Mosley, Rebecca F Gottesman, Priya Palta |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |