Genome‐wide mediation analysis reveals amyloid and tau imaging genetics patterns in Alzheimer’s Disease
Shizhuo Mu, Saima Rathore, Jingxuan Bao, Shu Yang, Basavaraj Hooli, Li Shen, for the ADNI · 2025
Read Genome‐wide mediation analysis reveals amyloid and tau imaging genetics patterns in Alzheimer’s Disease by Shizhuo Mu, Saima Rathore, Jingxuan Bao, Shu Yang, Basavaraj Hooli, Li Shen, for the ADNI (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715476.txt.
Description
Shizhuo Mu and co-authors published a 2025 study on genes, brain imaging, and memory in Alzheimer disease. Two proteins, amyloid and tau, build up in the brain in this disease, but how genes act through them on thinking was unclear. The team used a method that tests whether a middle factor carries an effect from one end to the other.
They used data from a large Alzheimer study group, with gene data plus amyloid scans for 1,051 people and tau scans for 525. First they scanned the genome for variants linked to test scores. Then they tested whether protein build up in 68 brain areas carried the gene effects on two thinking tests. The work maps paths from gene variants to brain changes to scores.
Catalog record
| CREATOR | Shizhuo Mu, Saima Rathore, Jingxuan Bao, Shu Yang, Basavaraj Hooli, Li Shen, for the ADNI |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |