Investigating differences in white matter fibre bundle alterations between amnestic Alzheimer’s disease and LATE: A fixel‐based analysis
Aurélie Lebrun, Julien Lagarde, Yann Leprince, Pauline Olivieri, Michel Bottlaender, Marie Sarazin · 2025
Read Investigating differences in white matter fibre bundle alterations between amnestic Alzheimer’s disease and LATE: A fixel‐based analysis by Aurélie Lebrun, Julien Lagarde, Yann Leprince, Pauline Olivieri, Michel Bottlaender, Marie Sarazin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715472.txt.
Description
Aurélie Lebrun and co-authors compare white-matter damage in two look-alike dementias in a 2025 study. Alzheimer's disease and LATE start with the same memory-led picture but involve different rogue proteins. If proteins spread along fiber pathways, the bundle damage should differ by disease. The team used high-quality diffusion MRI with fixel-based analysis, which resolves crossing fibers.
Groups were matched tightly: twenty-seven Alzheimer's patients, eighteen presumed LATE patients, and nineteen controls, all with mild impairment and equal memory scores. Diagnosis rested on fluid biomarkers, brain scans, and two clean years of follow-up. Whole-brain analysis then hunted for bundle differences tied to each proteinopathy. The study design isolates pathophysiology from symptom severity, a rare clean comparison. Results map where each disease's wiring breaks down.
Catalog record
| CREATOR | Aurélie Lebrun, Julien Lagarde, Yann Leprince, Pauline Olivieri, Michel Bottlaender, Marie Sarazin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |