Untargeted metabolomics tools to inform diet and drug exposures of cognitively declined cohorts
Haoqi Nina Zhao, Ipsita Mohanty, Rima F. Kaddurah‐Daouk, Alzheimer's Gut Microbiome Project Consortium (AGMP), Pieter Dorrestein · 2025
Read Untargeted metabolomics tools to inform diet and drug exposures of cognitively declined cohorts by Haoqi Nina Zhao, Ipsita Mohanty, Rima F. Kaddurah‐Daouk, Alzheimer's Gut Microbiome Project Consortium (AGMP), Pieter Dorrestein (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715458.txt.
Description
Haoqi Nina Zhao and co-authors present two tools that read diet and drug exposure from chemical fingerprints. Their 2025 paper uses untargeted metabolomics, which scans a sample's small molecules without a fixed target list. Two resources anchor the work. One is a reference set of some 3,500 foods with their spectra. The other is a drug library searched against over a billion public spectra.
The food tool traced a known Alzheimer's marker to lentils, and its diet score separated participants in a Mediterranean diet trial by their profiles. The drug tool found over a hundred drugs in brain samples from a long-running aging study, nerve, mood, and heart drugs the biggest groups. It found nearly two hundred drugs in stool samples from another cohort. A Parkinson's drug appeared in almost two thirds of one patient group. The authors offer both tools for exposure research in aging cohorts.
Catalog record
| CREATOR | Haoqi Nina Zhao, Ipsita Mohanty, Rima F. Kaddurah‐Daouk, Alzheimer's Gut Microbiome Project Consortium (AGMP), Pieter Dorrestein |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |