Effect of Scanner on beta amyloid quantification in a head‐to‐head comparison of 18F‐NAV4694 Centiloid measurements between Biograph Vision, Gemini and Biograph mCT
Vincent Dore, Ashley G Gillman, Pierrick Bourgeat, Victor L Villemagne, Jurgen Fripp, Kun Huang, Robert Williams, Rosita Shishegar, Graeme O'Keefe, Timothy Cox, Shenpeng Li, Natasha Krishnadas, Azadeh Feizpour, Svetlana Bozinovski, Christopher C Rowe · 2025
Read Effect of Scanner on beta amyloid quantification in a head‐to‐head comparison of 18F‐NAV4694 Centiloid measurements between Biograph Vision, Gemini and Biograph mCT by Vincent Dore, Ashley G Gillman, Pierrick Bourgeat, Victor L Villemagne, Jurgen Fripp, Kun Huang, Robert Williams, Rosita Shishegar, Graeme O'Keefe, Timothy Cox, Shenpeng Li, Natasha Krishnadas, Azadeh Feizpour, Svetlana Bozinovski, Christopher C Rowe (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715387.txt.
Description
Vincent Dore and fifteen colleagues show that swapping PET scanners shifts measured brain amyloid levels, in a 2025 paper. Amyloid burden is scored on the Centiloid scale to compare patients across tracers and pipelines. Newer scanners are sharper, but the scale was never designed to absorb hardware changes.
Twenty-eight study participants were scanned on two machines within a year, drawn from three scanner models. Even after standard smoothing meant to harmonize resolution, the newest scanner read significantly higher than both older ones. The gap grew with the burden itself: negligible near zero, but about ten percent higher at the top of the scale. Smoothing removed at most a fifth of the difference. The authors warn that scanner upgrades can masquerade as disease change in trials. Longitudinal studies, they imply, should track hardware as carefully as biology.
Catalog record
| CREATOR | Vincent Dore, Ashley G Gillman, Pierrick Bourgeat, Victor L Villemagne, Jurgen Fripp, Kun Huang, Robert Williams, Rosita Shishegar, Graeme O'Keefe, Timothy Cox, Shenpeng Li, Natasha Krishnadas, Azadeh Feizpour, Svetlana Bozinovski, Christopher C Rowe |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |