The unique contribution of tau pathology in the amygdala to depressive symptoms in cognitively normal older adults
Teodora Z. Markova, Corrina S. Fonseca, Claire J. Ciampa, Alice Murphy, Susan M. Landau, Theresa M. Harrison, William J. Jagust, Anne S. Berry · 2025
Read The unique contribution of tau pathology in the amygdala to depressive symptoms in cognitively normal older adults by Teodora Z. Markova, Corrina S. Fonseca, Claire J. Ciampa, Alice Murphy, Susan M. Landau, Theresa M. Harrison, William J. Jagust, Anne S. Berry (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715384.txt.
Description
Teodora Markova and co-authors link a brain protein to low mood in older adults in a 2025 study. Tau, a protein that tangles in Alzheimer's disease, builds up early in deep brain areas. Most scan studies focus on a memory region, but the amygdala, an emotion hub, also collects tau in people who still think normally. The team asked whether that deposit tracks depressive symptoms over time.
They ran matching analyses in two cohorts of non-depressed older adults, one national and one from Berkeley. All had tau scans, amyloid status, gene risk data, and repeated mood and memory scores. Carriers of a known risk gene held more amygdala tau. The study tests whether amygdala tau by itself, apart from amyloid, predicts rising depressive symptoms.
Catalog record
| CREATOR | Teodora Z. Markova, Corrina S. Fonseca, Claire J. Ciampa, Alice Murphy, Susan M. Landau, Theresa M. Harrison, William J. Jagust, Anne S. Berry |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |