Longitudinal Trajectories of Blood‐based biomarkers for Alzheimer’s Disease in Subjective Cognitive Decline; the SCIENCe project
Calvin Trieu, Argonde C van Harten, Mardou S S A van Leeuwenstijn, Lisa‐Marie Schlüter, Inge MW Verberk, Lynn Boonkamp, Azzam Aladdin, Charlotte Teunissen, Wiesje M van der Flier · 2025
Read Longitudinal Trajectories of Blood‐based biomarkers for Alzheimer’s Disease in Subjective Cognitive Decline; the SCIENCe project by Calvin Trieu, Argonde C van Harten, Mardou S S A van Leeuwenstijn, Lisa‐Marie Schlüter, Inge MW Verberk, Lynn Boonkamp, Azzam Aladdin, Charlotte Teunissen, Wiesje M van der Flier (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715381.txt.
Description
Calvin Trieu and co-authors tracked blood signs of Alzheimer's disease in people who feel their memory slip. The state is called subjective cognitive decline, when tests still read as normal. Blood tests can now flag the disease years before clear signs. The team asked how three such signs move over time in this group.
They drew on a Dutch clinic cohort of two hundred ninety-eight adults. About a third of the group had amyloid in the brain at the start. Blood was drawn about each two years for more than five years on the whole. One amyloid score started low in the amyloid group and stayed flat. Two harm signs started high and rose, one of them faster in the amyloid group. People who went on to clear thought loss also started with worse scores. The paths may help sort who needs close watch as years pass.
Catalog record
| CREATOR | Calvin Trieu, Argonde C van Harten, Mardou S S A van Leeuwenstijn, Lisa‐Marie Schlüter, Inge MW Verberk, Lynn Boonkamp, Azzam Aladdin, Charlotte Teunissen, Wiesje M van der Flier |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |