Cross‐cohort epigenome‐wide association study in Alzheimer’s disease risk and related traits
Lidija Milicic, Michael Vacher, Tenielle Porter, Vincent Dore, Pierrick Bourgeat, James D. Doecke, Rosita Shishegar, Paul Maruff, Colin L. Masters, Christopher C. Rowe, Victor L Villemagne, Simon M. Laws · 2025
Read Cross‐cohort epigenome‐wide association study in Alzheimer’s disease risk and related traits by Lidija Milicic, Michael Vacher, Tenielle Porter, Vincent Dore, Pierrick Bourgeat, James D. Doecke, Rosita Shishegar, Paul Maruff, Colin L. Masters, Christopher C. Rowe, Victor L Villemagne, Simon M. Laws (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715378.txt.
Description
Single DNA methylation sites linked to Alzheimer's disease carry weak signals each, so Lidija Milicic and co-authors borrow the genetics trick of summing many sites into a risk score. They run epigenome-wide scans in an Australian cohort of 707 people against eight traits, from disease risk to brain volumes and memory scores, then build methylation risk scores from the results.
No single site survived strict correction. Several combined scores did associate with Alzheimer's risk in the second cohort of 620 people, even after correction. The 2025 study suggests the methylation signal for Alzheimer's is real but spread thin, readable only in aggregate.
Catalog record
| CREATOR | Lidija Milicic, Michael Vacher, Tenielle Porter, Vincent Dore, Pierrick Bourgeat, James D. Doecke, Rosita Shishegar, Paul Maruff, Colin L. Masters, Christopher C. Rowe, Victor L Villemagne, Simon M. Laws |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |