Associations between basal forebrain volume and cognitive decline in GBA and LRRK2 mutation carriers from asymptomatic stages to Parkinson’s disease
Julia Schumacher, Stefan Teipel, Alexander Storch · 2025
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Description
Julia Schumacher, Stefan Teipel, and Alexander Storch studied a brain region tied to memory and attention in people who carry certain gene changes, in a 2025 paper. The gene changes, in genes called GBA and LRRK2, raise the risk of Parkinson's disease and shape its course. The team measured the size of the basal forebrain, a small area that supplies a key messenger for thinking.
The study drew on a large shared dataset with hundreds of carriers, patients, and healthy adults. Carriers without symptoms had a larger basal forebrain than healthy adults, which surprised the team. Once disease began, one carrier group kept larger volumes and lost thinking skills more slowly than others. The authors suggest this brain area follows different paths in each genetic form of the disease.
Catalog record
| CREATOR | Julia Schumacher, Stefan Teipel, Alexander Storch |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |