Head‐to‐Head Comparison of Plasma vs. Saliva Extracellular Vesicle Subpopulations Derived Normal Controls and Cognitively Impaired Subjects
Charisse N. Winston, Floyd Sarsoza · 2025
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Description
Charisse Winston and Floyd Sarsoza present a 2025 study comparing tiny cell parcels, called extracellular vesicles, in blood and saliva as possible Alzheimer's test material. Vesicles shed by brain cells carry disease proteins, and blood versions already show diagnostic promise. The team asked whether saliva, far easier to collect, holds comparable parcels in healthy adults and people with mild cognitive impairment.
Matched blood and saliva samples were enriched for neuron-derived vesicles and profiled for size, shape, and marker proteins. The two fluids held overlapping but distinct vesicle families; one common marker appeared only in blood, and antibody choice changed which parcels were detected. Disease proteins were slated for precise measurement. The work maps what a saliva-based Alzheimer's test would need to handle.
Catalog record
| CREATOR | Charisse N. Winston, Floyd Sarsoza |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |