Peak width of skeletonized mean diffusivity might be a better neuroimage marker for cognitive functions in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)
Wei‐Ju Lee, Fan Huang, Shi‐Ming Wang, Hung‐Chieh Chen, Yi‐Ming Chen, Hsu‐Wen Huang, Chih‐Mao Huang · 2025
Read Peak width of skeletonized mean diffusivity might be a better neuroimage marker for cognitive functions in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) by Wei‐Ju Lee, Fan Huang, Shi‐Ming Wang, Hung‐Chieh Chen, Yi‐Ming Chen, Hsu‐Wen Huang, Chih‐Mao Huang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715306.txt.
Description
Wei-Ju Lee and co-authors hunted a better scan mark for thought skills in a rare passed-down vessel disease. The disease, called CADASIL, stems from a flaw in one gene and harms small brain vessels. White spots on scans are its classic sign, yet they track thought skills poorly. A newer mark reads how wide the spread of water flow is in white matter tracts.
The team scanned gene carriers with no past stroke or dementia and a matched set of non-carriers. All took tests of memory, speed, planning, and space skills. Carriers showed worse white spots and a wider spread mark than non-carriers. The spread mark lined up with slower speed and weaker space skills once age and schooling were weighed. The white spot load showed no such link, which puts the new mark ahead.
Catalog record
| CREATOR | Wei‐Ju Lee, Fan Huang, Shi‐Ming Wang, Hung‐Chieh Chen, Yi‐Ming Chen, Hsu‐Wen Huang, Chih‐Mao Huang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |