Mediation of Physical Activity Patterns between Whiter Matter Microstructure Alteration and Cognitive Decline According to the Progression of Alzheimer's Disease
Narae Kim, Hyun Woong Roh, Sang Joon Son, Bumhee Park · 2025
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Description
Narae Kim and co-authors test whether daily movement carries the effect of brain wiring damage onto thinking, as Alzheimer's disease advances. Activity is known to guard cognition, but its role may change by stage. Using a Korean cohort of 131 people, split into amyloid-negative and amyloid-positive mild impairment and full disease, the team combined wiring scans, wrist activity patterns, and memory scores in a mediation model.
In the amyloid-positive impairment group, movement clearly mediated the link: twenty regions' wiring effects ran through peak activity levels, twenty-four through day-to-day rhythm stability. In full disease the thread nearly vanished, and without amyloid it never appeared. The window for activity to protect, they argue, is before dementia sets in.
Catalog record
| CREATOR | Narae Kim, Hyun Woong Roh, Sang Joon Son, Bumhee Park |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |