Principal Component Analysis discriminates lipid metabolites in the plasma of individuals with MCI, Alzheimer's, and Down Syndrome
Tamires Alves Sarno, Cícero Augusto Costa Pereira, Leda Leme Talib, Wagner Farid Gattaz, Orestes Vicente Forlenza · 2025
Read Principal Component Analysis discriminates lipid metabolites in the plasma of individuals with MCI, Alzheimer's, and Down Syndrome by Tamires Alves Sarno, Cícero Augusto Costa Pereira, Leda Leme Talib, Wagner Farid Gattaz, Orestes Vicente Forlenza (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715241.txt.
Description
Tamires Alves Sarno and co-authors sort blood lipids across brain health groups in a 2025 study. Fat metabolism faults have been tied to Alzheimer disease, and traces may show in blood long before deep decline. The team read plasma lipids in six groups of 17 people each, from young and old healthy adults to mild impairment, Alzheimer, and Down syndrome.
A mass spectrometry scan logged 208 lipids per sample. A pattern method then picked 29 lipids that split the groups apart. The lead module rests on a lysophosphatidylcholine family. Such panels could aid early calls on who drifts toward dementia.
Catalog record
| CREATOR | Tamires Alves Sarno, Cícero Augusto Costa Pereira, Leda Leme Talib, Wagner Farid Gattaz, Orestes Vicente Forlenza |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |