Data driven subtyping of individuals on the Alzheimer’s continuum using cortical microstructure from diffusion MRI
Shayan Javid, Alyssa H Zhu, Iyad Ba Gari, Neda Jahanshad, Talia M Nir · 2025
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Description
Shayan Javid and co-authors sorted, in a 2025 study, people on the Alzheimer's path into subtypes using diffusion scans of the cortex. Alzheimer's changes begin years before shrinkage shows on standard scans or memory slips. Diffusion imaging reads the fine grain of tissue, which may shift earlier.
The team pooled 484 participants from one study and 188 from another. A staging model grouped people by how diffusivity had risen across brain regions, and separately by thickness and volume. The point was to see whether scan-based subtypes also differ in thinking scores and in spinal fluid or PET markers of amyloid and tau. Early, unlike patterns of decline could one day guide who gets which trial or treatment. Subtyping by microstructure adds a lens that size alone cannot give.
Catalog record
| CREATOR | Shayan Javid, Alyssa H Zhu, Iyad Ba Gari, Neda Jahanshad, Talia M Nir |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |