Differentiating Parkinson‐Plus Syndromes from Other Neurodegenerative Diseases Using Automated T1 MRI Quantification
Elena M Bonke, Juha Koikkalainen, Antti Tolonen, Juhana Hakumäki, Patrizia Mecocci, Steen G Hasselbalch, Hanneke FM Rhodius‐ Meester, Bas Jasperse, Afina Willemina Lemstra, Wiesje M van der Flier, Frederik Barkhof, Jyrki Lötjönen · 2025
Read Differentiating Parkinson‐Plus Syndromes from Other Neurodegenerative Diseases Using Automated T1 MRI Quantification by Elena M Bonke, Juha Koikkalainen, Antti Tolonen, Juhana Hakumäki, Patrizia Mecocci, Steen G Hasselbalch, Hanneke FM Rhodius‐ Meester, Bas Jasperse, Afina Willemina Lemstra, Wiesje M van der Flier, Frederik Barkhof, Jyrki Lötjönen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715186.txt.
Description
Elena Bonke and co-authors test in 2025 whether automatic measures from standard brain scans can tell Parkinson plus syndromes apart from other brain diseases. Correctly naming these disorders is hard, yet the name steers care, above all as disease slowing drugs arrive for Alzheimer's disease. The team mined the common structural scan type for markers.
Scans came from 1,206 people across three cohorts, spanning dementia and Parkinson groups. Software measured brain volumes without human tracing. The markers were checked for how well they split the atypical Parkinson syndromes from Alzheimer's, plain Parkinson's, and healthy peers. A scan score that sorts these look alike diseases could spare patients years of wrong treatment. It could also clean up trial enrollment.
Catalog record
| CREATOR | Elena M Bonke, Juha Koikkalainen, Antti Tolonen, Juhana Hakumäki, Patrizia Mecocci, Steen G Hasselbalch, Hanneke FM Rhodius‐ Meester, Bas Jasperse, Afina Willemina Lemstra, Wiesje M van der Flier, Frederik Barkhof, Jyrki Lötjönen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |