Potential Relative Effect of Intensive Systolic Blood Pressure Control on Preventing White Matter Damage Across Age Groups
Jeremy J Pruzin, Kyle C Kern, David M Reboussin, William C Cushman, Aditi Gupta, Clinton B Wright, Jeff D Williamson, Pierre N Tariot, Ilya M Nasrallah, Nicholas M Pajewski · 2025
Read Potential Relative Effect of Intensive Systolic Blood Pressure Control on Preventing White Matter Damage Across Age Groups by Jeremy J Pruzin, Kyle C Kern, David M Reboussin, William C Cushman, Aditi Gupta, Clinton B Wright, Jeff D Williamson, Pierre N Tariot, Ilya M Nasrallah, Nicholas M Pajewski (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715185.txt.
Description
Jeremy J Pruzin and co-authors asked if hard blood pressure control guards the brain's white matter more in the young-old than the old-old. A big US trial had shown that a lower pressure goal slowed white matter harm on scans. The team split the trial's scan group by age to test the hunch. Two scan marks tracked the harm: spot load and a spread mark of water flow.
In the hard-control arm, mean pressure ran well below the plain arm over about four years. The cut in harm growth was largest in those under sixty-five, at about seventy-three percent. It was about half that in the mid band and about a fifth in those past seventy-five. Both scan marks told the same tale. Yet the age split fell short of a firm stats bar, so the trend needs a test in more scans.
Catalog record
| CREATOR | Jeremy J Pruzin, Kyle C Kern, David M Reboussin, William C Cushman, Aditi Gupta, Clinton B Wright, Jeff D Williamson, Pierre N Tariot, Ilya M Nasrallah, Nicholas M Pajewski |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |