T1/T2 weighted ratio mapping to assess intracortical myelination in autosomal dominant Alzheimer's disease
Alessia Sgalia, Dilek Ocal, Thomas Veale, Damien Ferguson, Antoinette O'Connor, Ian B. Malone, David M Cash, Nick C Fox, Philip SJ Weston · 2025
Read T1/T2 weighted ratio mapping to assess intracortical myelination in autosomal dominant Alzheimer's disease by Alessia Sgalia, Dilek Ocal, Thomas Veale, Damien Ferguson, Antoinette O'Connor, Ian B. Malone, David M Cash, Nick C Fox, Philip SJ Weston (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715176.txt.
Description
Alessia Sgalia and co-authors used a scan ratio to gauge myelin in the brains of families with inherited Alzheimer disease in a 2025 paper. Myelin, the coating on nerve fibers, changes in this disease but gets less study than amyloid or tau. The inherited form lets researchers estimate years to symptom onset from family history. That makes it a good setting to track early change.
Seventy two family members took part: carriers of the disease mutation with and without symptoms, plus non carrier controls. Each had two kinds of MRI scan, and the team formed a ratio map meant to reflect myelin in the cortex. Maps were compared between groups, with age and sex accounted for. In carriers, the team also tested how the ratio moves with estimated years from onset. The study tests whether this easy scan measure can serve as a window on a neglected part of disease.
Catalog record
| CREATOR | Alessia Sgalia, Dilek Ocal, Thomas Veale, Damien Ferguson, Antoinette O'Connor, Ian B. Malone, David M Cash, Nick C Fox, Philip SJ Weston |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |