Synergistic effects of plasma S100b levels and MRI‐based water exchange rate across the blood‐brain‐barrier on memory performance among older adults
Colleen Pappas, Valentinos Zachariou, Christopher E Bauer, Tiffany L Sudduth, Donna M Wilcock, Gregory A Jicha, Anika MS Hartz, Xingfeng Shao, Danny JJ Wang, Brian T Gold · 2025
Read Synergistic effects of plasma S100b levels and MRI‐based water exchange rate across the blood‐brain‐barrier on memory performance among older adults by Colleen Pappas, Valentinos Zachariou, Christopher E Bauer, Tiffany L Sudduth, Donna M Wilcock, Gregory A Jicha, Anika MS Hartz, Xingfeng Shao, Danny JJ Wang, Brian T Gold (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715157.txt.
Description
Colleen Pappas and co-authors test two non-invasive markers of blood-brain barrier health against memory in older adults in a 2025 study. A leaky barrier may speed small vessel disease in the brain. Blood levels of a protein tied to astrocyte injury, and an MRI measure of water exchange across the barrier, offer windows on that leak.
Seventy-four adults without dementia gave blood, scans, and cognitive tests. The two markers interacted: their combination related to memory more than either alone in the analysis. Early, cheap detection of barrier failure could flag patients for prevention trials before stroke or dementia declares itself.
Catalog record
| CREATOR | Colleen Pappas, Valentinos Zachariou, Christopher E Bauer, Tiffany L Sudduth, Donna M Wilcock, Gregory A Jicha, Anika MS Hartz, Xingfeng Shao, Danny JJ Wang, Brian T Gold |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |