Developing an AI algorithm to detect predictors of poor performance in a self‐administered, web‐based digital biomarker for Alzheimer’s Disease: proof of concept
Joe Butler, Adewale Samuel Owo, Tamlyn J Watermeyer, Samuel O. Danso, Mario A Parra‐Rodriguez, Binding in Neuropsychiatric Disorders (BIND) Group · 2025
Read Developing an AI algorithm to detect predictors of poor performance in a self‐administered, web‐based digital biomarker for Alzheimer’s Disease: proof of concept by Joe Butler, Adewale Samuel Owo, Tamlyn J Watermeyer, Samuel O. Danso, Mario A Parra‐Rodriguez, Binding in Neuropsychiatric Disorders (BIND) Group (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715129.txt.
Description
Joe Butler and co-authors built a proof-of-concept study in 2025 around a web task for memory. The task tests how well a person binds shapes and colors in short-term memory. Weak scores on it have been tied to Alzheimer's disease, even before clear signs show. The group asked if smart software could flag who does poorly, and why.
They used data from three hundred fifty-nine adults who took the task online. Each person got a binding cost score that split the group into strong and weak binders. Three learning methods were trained on age, sex, schooling, body mass, and health facts. The best of the three sorted people with about ninety-one percent accuracy. Apart from more health problems among weak binders, the groups looked much the same. The team frames the tool as an early step toward cheap, at-home screening.
Catalog record
| CREATOR | Joe Butler, Adewale Samuel Owo, Tamlyn J Watermeyer, Samuel O. Danso, Mario A Parra‐Rodriguez, Binding in Neuropsychiatric Disorders (BIND) Group |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |