Retinal imaging in polarized light of two different protein deposit types found in the retina in different neurodegeneration diseases (NDDs)
Melanie CW Campbell, Hannah Gallop, Erik L Mason, Laura Emptage, Rachel Redekop, Monika Kitor, Ging‐Yuek Robin Hsiung, Ian R MacKenzie, Veronica Hirsch‐Reinshagen · 2025
Read Retinal imaging in polarized light of two different protein deposit types found in the retina in different neurodegeneration diseases (NDDs) by Melanie CW Campbell, Hannah Gallop, Erik L Mason, Laura Emptage, Rachel Redekop, Monika Kitor, Ging‐Yuek Robin Hsiung, Ian R MacKenzie, Veronica Hirsch‐Reinshagen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715128.txt.
Description
Melanie Campbell and co-authors used light tricks to tell two kinds of protein clumps apart in the eye. The retina at the back of the eye is part of the brain's own tissue. Clumps of amyloid mark Alzheimer's disease, while clumps of alpha synuclein mark two other brain diseases. If the eye shows which clump is which, a quick scan could sort patients early.
Donated eyes and brains came from twelve people with known brain states. The team lit the flat-mounted retinas with polarized light and read how each clump bent it. Hundreds of clumps were read across the three disease groups. On their own, most light measures blurred the two clump kinds. Mixed as a set, though, they let two smart programs sort the kinds well. The work backs the eye as a cheap window on brain disease.
Catalog record
| CREATOR | Melanie CW Campbell, Hannah Gallop, Erik L Mason, Laura Emptage, Rachel Redekop, Monika Kitor, Ging‐Yuek Robin Hsiung, Ian R MacKenzie, Veronica Hirsch‐Reinshagen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |