Longitudinal multicenter head‐to‐head harmonization of tau‐PET tracers: an overview of the HEAD study cohort
Firoza Z Lussier, Guilherme Povala, Guilherme Bauer‐Negrini, Livia Amaral, Juli Cehula, Devin J Fine, Peter Lemaire, Madeleine Bloomquist, Belen Pascual, Brian A Gordon, Val J Lowe, Hwamee Oh, David N soleimani‐meigooni, Pedro Rosa‐Neto, Dana Tudorascu, William J Jagust, William E Klunk, Suzanne L B · 2025
Read Longitudinal multicenter head‐to‐head harmonization of tau‐PET tracers: an overview of the HEAD study cohort by Firoza Z Lussier, Guilherme Povala, Guilherme Bauer‐Negrini, Livia Amaral, Juli Cehula, Devin J Fine, Peter Lemaire, Madeleine Bloomquist, Belen Pascual, Brian A Gordon, Val J Lowe, Hwamee Oh, David N soleimani‐meigooni, Pedro Rosa‐Neto, Dana Tudorascu, William J Jagust, William E Klunk, Suzanne L B (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715101.txt.
Description
Firoza Lussier and co-authors give an overview of a large study that scans the same people with several brain imaging tracers for tau protein, in work published in 2025. Tau buildup is a hallmark of Alzheimer disease, but each tracer binds in its own way, which makes results hard to compare across studies. The study spans sites in the United States and Canada.
More than six hundred people are planned, from young healthy adults to patients with Alzheimer disease. In the first year, over three hundred sixty joined, and most finished memory tests, MRI, and at least two tracer scans. Scans repeat after eighteen months. The authors aim to harmonize the tracers so findings can be shared across trials.
Catalog record
| CREATOR | Firoza Z Lussier, Guilherme Povala, Guilherme Bauer‐Negrini, Livia Amaral, Juli Cehula, Devin J Fine, Peter Lemaire, Madeleine Bloomquist, Belen Pascual, Brian A Gordon, Val J Lowe, Hwamee Oh, David N soleimani‐meigooni, Pedro Rosa‐Neto, Dana Tudorascu, William J Jagust, William E Klunk, Suzanne L B |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |