ApoE genotype and hippocampus have heterogenic influence on diagnosis and cognitive performance in the UCD ADRC longitudinal diversity cohort
Eva Min, Sarah Tomaszewski Farias, David K Johnson, Lee‐Way Jin, Pauline Maillard, Evan Fletcher, Rachel A Whitmer, Charles Decarli · 2025
Read ApoE genotype and hippocampus have heterogenic influence on diagnosis and cognitive performance in the UCD ADRC longitudinal diversity cohort by Eva Min, Sarah Tomaszewski Farias, David K Johnson, Lee‐Way Jin, Pauline Maillard, Evan Fletcher, Rachel A Whitmer, Charles Decarli (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715100.txt.
Description
Eva Min and co-authors weighed how a gene mark and a memory zone shape diagnosis in a mixed cohort. The cohort, run from Davis, California, spans White, Black, and Latino adults. Their thought runs from sharp to full dementia. Past work hints the gene mark may not act the same in each group, so the team split the group by roots as well as as a whole.
As a whole, the gene mark grew more common as thought state worsened. Carriers also had a smaller memory zone and worse scores on story memory tests. When the memory zone was put in the same model, both it and the gene mark still tracked memory. The team then read the links group by group to see where the gene's weight shifts. Such splits matter for fair use of gene tests in mixed clinics.
Catalog record
| CREATOR | Eva Min, Sarah Tomaszewski Farias, David K Johnson, Lee‐Way Jin, Pauline Maillard, Evan Fletcher, Rachel A Whitmer, Charles Decarli |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |