Relationship of Mito‐Nuclear Genetics to FDG‐PET Alzheimer’s Disease Biomarkers in Aging
Robyn A Honea, Eric D Vidoni, Rebecca J Lepping, Jill K Morris, Heather M Wilkins, Jeffrey M Burns, Russell H Swerdlow · 2025
Read Relationship of Mito‐Nuclear Genetics to FDG‐PET Alzheimer’s Disease Biomarkers in Aging by Robyn A Honea, Eric D Vidoni, Rebecca J Lepping, Jill K Morris, Heather M Wilkins, Jeffrey M Burns, Russell H Swerdlow (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715078.txt.
Description
Robyn A Honea and co-authors weighed how genes tied to cell power plants shape brain fuel use. The power plants, called mitochondria, carry their own small set of genes. Brain fuel use drops early in Alzheimer's disease, which hints that these genes may play a part. Two genes near the cell core were in the frame as well.
The team used data from a Kansas aging cohort with three groups of adults. One group had the disease, one had mild thought loss, and one had neither. All had scans that map how much sugar each brain zone burns. Carriers of a known risk gene burned less sugar in zones at the front and midline of the brain. Two other gene marks showed no such link in the healthy group. The split points to the risk gene, not the power-plant genes, as the driver here.
Catalog record
| CREATOR | Robyn A Honea, Eric D Vidoni, Rebecca J Lepping, Jill K Morris, Heather M Wilkins, Jeffrey M Burns, Russell H Swerdlow |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |