From glia to cytokine signatures across the Alzheimer’s spectrum
Maura Malpetti, Peter Swann, Leonidas Chouliaras, P Simon Jones, Elijah Mak, W Richard Bevan‐Jones, Li Su, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John T O'Brien, James B Rowe · 2025
Read From glia to cytokine signatures across the Alzheimer’s spectrum by Maura Malpetti, Peter Swann, Leonidas Chouliaras, P Simon Jones, Elijah Mak, W Richard Bevan‐Jones, Li Su, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John T O'Brien, James B Rowe (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715059.txt.
Description
Maura Malpetti and co-authors linked blood signs of swelling to brain swelling across the Alzheimer's disease span. Swelling in the brain starts early in the disease and may speed decline. Drug trials that aim at swelling need signs they can track in the living brain and blood. The team paired blood samples with a scan that lights up active guard cells in the brain.
The sample held healthy adults and patients with mild thought loss or the full disease. A stats tool sorted thirty blood swelling signs into two broad themes. Both themes were rich in signs that drive swelling on. One theme ran higher in the disease group than in the other two groups. That theme also rose in step with the brain scan across wide zones. The blood theme may thus mirror swelling in the brain itself.
Catalog record
| CREATOR | Maura Malpetti, Peter Swann, Leonidas Chouliaras, P Simon Jones, Elijah Mak, W Richard Bevan‐Jones, Li Su, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John T O'Brien, James B Rowe |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |