BDNF Val66Met polymorphism moderates the neuroprotective effects of physical activity in older adults
Claire J. Cadwallader, David Luke Fischer, Anna M. VandeBunte, Coty Chen, Valentina E. Diaz, Shannon Y. Lee, Brandon Chan, Argentina Lario Lago, Julio C. Rojas, Joel H. Kramer, Emily W. Paolillo, Rowan Saloner, Kaitlin B. Casaletto · 2025
Read BDNF Val66Met polymorphism moderates the neuroprotective effects of physical activity in older adults by Claire J. Cadwallader, David Luke Fischer, Anna M. VandeBunte, Coty Chen, Valentina E. Diaz, Shannon Y. Lee, Brandon Chan, Argentina Lario Lago, Julio C. Rojas, Joel H. Kramer, Emily W. Paolillo, Rowan Saloner, Kaitlin B. Casaletto (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715055.txt.
Description
Exercise guards the aging brain, but a common gene variant may blunt that guard for some people. Claire J Cadwallader and co-authors tested that idea in a 2025 study of older adults without dementia. One hundred twenty-three people from a San Francisco memory center took part. Wrist trackers logged daily steps for thirty days. Blood tests measured a disease marker, and gene tests split the group by variant.
The variant in question lowers release of a growth factor that exercise normally raises. Carriers made up about two fifths of the group. The team tested whether the variant changed how steps tracked with the blood marker and with thinking scores. Memory and executive skills were scored as combined measures. The design links genes, habits, and brain health in one frame.
Catalog record
| CREATOR | Claire J. Cadwallader, David Luke Fischer, Anna M. VandeBunte, Coty Chen, Valentina E. Diaz, Shannon Y. Lee, Brandon Chan, Argentina Lario Lago, Julio C. Rojas, Joel H. Kramer, Emily W. Paolillo, Rowan Saloner, Kaitlin B. Casaletto |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |