Effect of kidney function on plasma pTau217 concentrations using different pTau217 assays
Alicia Algeciras‐Schimnich · 2025
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Description
Alicia Algeciras-Schimnich, writing solo in 2025, asked if weak kidneys skew a blood test for Alzheimer's disease. The test reads a tau sign in blood, and its use is growing fast in clinics. Chronic kidney disease has been tied to higher reads on the test. If the kidney link is real, some high reads may not mean brain disease at all.
The sample held one hundred ninety-five adults from two Mayo Clinic studies. Some had sharp thought, some mild loss, and a few the full disease. Three lab ways to read the tau sign were set side by side. As kidney work fell, the tau read rose on all three, by up to about a fourth for a set drop. A form of the test built as a ratio did not rise with kidney loss. That ratio may dodge the kidney trap.
Catalog record
| CREATOR | Alicia Algeciras‐Schimnich |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |