Sex, racial/ethnic, and APOE‐ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging
Amalia Jo Peterson, Aditi Sathe, Yisu Yang, Alaina Durant, Niranjana Shashikumar, Kimberly R Pechman, Logan C Dumitrescu, Katherine A Gifford, Shannon L Risacher, Lori L Beason‐Held, Yang An, Kurt Schilling, Bennett A Landman, Julie A Schneider, Lisa L Barnes, David A Bennett, Angela L Jefferson, Su · 2025
Read Sex, racial/ethnic, and APOE‐ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging by Amalia Jo Peterson, Aditi Sathe, Yisu Yang, Alaina Durant, Niranjana Shashikumar, Kimberly R Pechman, Logan C Dumitrescu, Katherine A Gifford, Shannon L Risacher, Lori L Beason‐Held, Yang An, Kurt Schilling, Bennett A Landman, Julie A Schneider, Lisa L Barnes, David A Bennett, Angela L Jefferson, Su (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715043.txt.
Description
Amalia Jo Peterson and co-authors study white matter change with aging in a 2025 paper across several long-term cohorts. White matter carries signals between brain areas, and its fine structure weakens in Alzheimer disease. The team asked whether that change over time differs by sex, by racial or ethnic group, and by carrying a gene variant tied to Alzheimer risk.
Data covered 2,619 participants aged fifty and older, with 6,837 imaging sessions in all. Diffusion scans were cleaned, corrected for free water, and harmonized across cohorts before modeling. The team tracked 48 white matter tracts and adjusted for age, education, thinking status, and other factors. The study gives a broad base for comparing how brain wiring ages across groups.
Catalog record
| CREATOR | Amalia Jo Peterson, Aditi Sathe, Yisu Yang, Alaina Durant, Niranjana Shashikumar, Kimberly R Pechman, Logan C Dumitrescu, Katherine A Gifford, Shannon L Risacher, Lori L Beason‐Held, Yang An, Kurt Schilling, Bennett A Landman, Julie A Schneider, Lisa L Barnes, David A Bennett, Angela L Jefferson, Su |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |