A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting
Hannah Baumeister, Jacob W. Vogel, Philip S. Insel, Luca Kleineidam, Steffen Wolfsgruber, Melina Stark, Helena M. Gellersen, Renat Yakupov, Matthias Schmid, Falk Lüsebrink, Frederic Brosseron, Gabriel Ziegler, Silka Dawn Freiesleben, Lukas Preis, Luisa Sophie Schneider, Eike Jakob Spruth, Slawek Alt · 2025
Read A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting by Hannah Baumeister, Jacob W. Vogel, Philip S. Insel, Luca Kleineidam, Steffen Wolfsgruber, Melina Stark, Helena M. Gellersen, Renat Yakupov, Matthias Schmid, Falk Lüsebrink, Frederic Brosseron, Gabriel Ziegler, Silka Dawn Freiesleben, Lukas Preis, Luisa Sophie Schneider, Eike Jakob Spruth, Slawek Alt (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715030.txt.
Description
Hannah Baumeister and co-authors built a data-led model in 2025 of how brain shrinkage differs across memory clinic patients. Such patients have mixed causes of poor aging, so one path of decline may not fit all. The team asked if known split paths, first seen in one disease group, show up in clinic life too.
A smart sorting tool was run on brain scans from 813 people in a German study group. Their average age was about seventy-one, and just over half were women. The model sorts people by both type and stage of shrinkage. Work like this could help clinics group patients more fairly for care and trials, since two people with the same score may be on quite different paths in the brain.
Catalog record
| CREATOR | Hannah Baumeister, Jacob W. Vogel, Philip S. Insel, Luca Kleineidam, Steffen Wolfsgruber, Melina Stark, Helena M. Gellersen, Renat Yakupov, Matthias Schmid, Falk Lüsebrink, Frederic Brosseron, Gabriel Ziegler, Silka Dawn Freiesleben, Lukas Preis, Luisa Sophie Schneider, Eike Jakob Spruth, Slawek Alt |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |