Harmonization of diffusion MRI measures is crucial for white matter tract normative assessment in ADNI
Maxime Descoteaux, Gabriel Girard, Manon Edde, Félix Dumais, Matthieu Dumont, Jean‐Christophe Houde, Pierre‐Marc Jodoin, Jean‐Rene Belanger · 2025
Read Harmonization of diffusion MRI measures is crucial for white matter tract normative assessment in ADNI by Maxime Descoteaux, Gabriel Girard, Manon Edde, Félix Dumais, Matthieu Dumont, Jean‐Christophe Houde, Pierre‐Marc Jodoin, Jean‐Rene Belanger (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715018.txt.
Description
Maxime Descoteaux leads a team of eight authors in 2025 in arguing that brain scan data from many hospitals must be harmonized before anyone builds norms from it. Diffusion MRI measures of white matter vary by site and scanner brand, biasing any pooled numbers.
The study works with the ADNI Alzheimer's cohort, taking twenty-one sites with at least ten participants each. It tests whether the standard harmonization method, ComBat, truly removes site bias for tract measurements, something not convincingly shown in this cohort before. Without that step, a patient could look abnormal merely for being scanned at the wrong hospital.
Catalog record
| CREATOR | Maxime Descoteaux, Gabriel Girard, Manon Edde, Félix Dumais, Matthieu Dumont, Jean‐Christophe Houde, Pierre‐Marc Jodoin, Jean‐Rene Belanger |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |