Diagnostic Performance and Clinical Applications of a Commercial Alpha‐Synuclein Seed Amplification Assay in a Tertiary Care Memory Clinic
Amanda Porter, Christian Lachner, Philip W Tipton, Neill R Graff‐Radford, Gregory S Day · 2025
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Description
Amanda Porter, Christian Lachner, Philip Tipton, Neill Graff-Radford, and Gregory Day test a shop-bought brain test in a real memory clinic, in a 2025 paper. The test spots clumped protein linked to Lewy body disease, a cause of dementia, in spinal fluid. In research banks the test scored high marks. The open question was whether it holds up in a mixed clinic crowd, where diagnoses are messy.
The clinic ran the test on stored fluid from about 200 patients with typical or fast-moving dementia. It found the protein in about a quarter of the typical group and a smaller share of the fast group. Among patients thought to have Lewy body disease, it caught only a third of cases, far below the banked-sample scores. The authors urge care in reading the test in daily practice.
Catalog record
| CREATOR | Amanda Porter, Christian Lachner, Philip W Tipton, Neill R Graff‐Radford, Gregory S Day |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |