Methodology of INDICATE: Investigating Neuromarkers for Decline & Impairment of Cognition After Thrombectomy for ELVO
Jordan P Harp, Justin F Fraser, Christopher J McLouth, Jacqueline A Frank, Jennifer Isaacs, Elise Dahlke, Keith R Pennypacker · 2025
Read Methodology of INDICATE: Investigating Neuromarkers for Decline & Impairment of Cognition After Thrombectomy for ELVO by Jordan P Harp, Justin F Fraser, Christopher J McLouth, Jacqueline A Frank, Jennifer Isaacs, Elise Dahlke, Keith R Pennypacker (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714983.txt.
Description
Jordan Harp and six co-authors lay out the design of a study hunting blood markers that predict thinking problems after stroke, in this 2025 methodology paper. A quarter to a third of stroke patients develop lasting cognitive impairment, yet clinicians cannot tell in advance who will. Their population, drawn seventy percent from Appalachia in the US Stroke Belt, is underserved and understudied.
The INDICATE study is prospectively enrolling 225 patients treated with thrombectomy for a large-vessel blockage. Arterial blood drawn during the procedure, and vein blood afterward, will be tracked against cognition, function, and social factors from three months to two years. The plasma panel covers Alzheimer's-related and inflammatory proteins. Earlier work from the team's registry found inflammation markers at procedure time that predicted later impairment; this study validates them in a broader sample with sharper cognitive measures.
Catalog record
| CREATOR | Jordan P Harp, Justin F Fraser, Christopher J McLouth, Jacqueline A Frank, Jennifer Isaacs, Elise Dahlke, Keith R Pennypacker |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |