Impaired baroreflex sensitivity and long‐term risk of dementia in community‐based older adults
Yuan Ma, Yiwen Zhang, Rikuta Hamaya, Berend E Westerhof, Hossam A Shaltout, Maryam Kavousi, Francesco U S Mattace Raso, Albert Hofman, Frank J. Wolters, Lewis A Lipsitz, M. Arfan Ikram · 2025
Read Impaired baroreflex sensitivity and long‐term risk of dementia in community‐based older adults by Yuan Ma, Yiwen Zhang, Rikuta Hamaya, Berend E Westerhof, Hossam A Shaltout, Maryam Kavousi, Francesco U S Mattace Raso, Albert Hofman, Frank J. Wolters, Lewis A Lipsitz, M. Arfan Ikram (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714963.txt.
Description
Yuan Ma and co-authors ask whether weak baroreflex sensitivity in old age warns of dementia years later. The baroreflex steadies blood pressure from beat to beat. Its role in dementia was unknown, though wide swings in pressure have been tied to risk. Their 2025 study uses the Rotterdam Study in the Netherlands. Reflex strength was read from five minutes of lying heart and pressure recordings in the late 1990s.
The group held 1,819 adults, and 421 developed dementia over a median follow-up of about 15 years. A weak reflex went with higher risk only in adults who took no blood pressure medication. In that group, the lowest fifth faced about 62 percent more risk than the highest fifth. Death risk also ran higher. The link held after checks for pressure level and variability. A weak reflex may be a new early sign.
Catalog record
| CREATOR | Yuan Ma, Yiwen Zhang, Rikuta Hamaya, Berend E Westerhof, Hossam A Shaltout, Maryam Kavousi, Francesco U S Mattace Raso, Albert Hofman, Frank J. Wolters, Lewis A Lipsitz, M. Arfan Ikram |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |