Temporal dynamic effects of cortical resilience proteins on trajectories of cognitive aging
Andrea R Zammit, Tianhao Wang, Lei Yu, Shahram Oveisgharan, Philip L De Jager, Vladislav A Petyuk, David A Bennett, Aron S Buchman · 2025
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Description
Andrea Zammit and co-authors published this study in two thousand twenty-five on brain proteins tied to resilience, the power to keep thinking well despite age or disease. Past work found such proteins in the cortex, some linked with slower decline and some with faster.
The team used two long studies of older adults, with more than a thousand people who took yearly thinking tests and gave brain tissue after death. They found forty proteins whose effects on decline spread across up to twenty-five years of follow-up. For the proteins tied to slower decline, effects could start more than two decades before death. For those tied to faster decline, effects bunched in the last seven years of life. The authors say the timing of each protein's effect varies a great deal.
Catalog record
| CREATOR | Andrea R Zammit, Tianhao Wang, Lei Yu, Shahram Oveisgharan, Philip L De Jager, Vladislav A Petyuk, David A Bennett, Aron S Buchman |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |