Longitudinal changes in amyloid, glucose, and glial reactivity imaging biomarkers in a transgenic rat model of amyloidosis
Gabriela Lazzarotto, Lidia Emmanuela Wiazowski Spelta, Cleinando Clemente da Silva Vera, Andreia Silva da Rocha, Débora Guerini de Souza, Daniele de Paula de Paula Faria, Eduardo R. Zimmer · 2025
Read Longitudinal changes in amyloid, glucose, and glial reactivity imaging biomarkers in a transgenic rat model of amyloidosis by Gabriela Lazzarotto, Lidia Emmanuela Wiazowski Spelta, Cleinando Clemente da Silva Vera, Andreia Silva da Rocha, Débora Guerini de Souza, Daniele de Paula de Paula Faria, Eduardo R. Zimmer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714882.txt.
Description
Gabriela Lazzarotto and co-authors follow brain scan markers over time in rats bred to develop amyloid disease, in a 2025 study. PET scans can now image amyloid plaques, sugar use, and immune cell reactivity in the living brain. Those markers reordered how Alzheimer's disease is staged. Whether rat models replay the same sequence was untested.
Transgenic rats and wild-type controls were scanned repeatedly. Amyloid, glucose, and glial signals were tracked as the animals aged. The order and timing of changes could then be compared with human disease. A faithful match would validate the model for drug testing. Mismatches would warn against over-trusting it. Preclinical researchers gain a calibration for a popular model.
Catalog record
| CREATOR | Gabriela Lazzarotto, Lidia Emmanuela Wiazowski Spelta, Cleinando Clemente da Silva Vera, Andreia Silva da Rocha, Débora Guerini de Souza, Daniele de Paula de Paula Faria, Eduardo R. Zimmer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |