Differences between high‐precision Alzheimer's disease plasma and PET biomarkers among cognitively normal older Black and White adults
Omonigho M Bubu, Allal Boutajangout, Ludovic Debure, Alok Vedvyas, Anthony Q Briggs, Mark A Bernard, Joshua L Gills, Elena Valkanova, Alfred Mbah, Mobeena Ghuman, Girardin A Jean‐Louis, Rebecca A Betensky, Karyn Marsh, Henry Rusinek, Ricardo S. Osorio, Thomas Wisniewski, Arjun V. Masurkar · 2025
Read Differences between high‐precision Alzheimer's disease plasma and PET biomarkers among cognitively normal older Black and White adults by Omonigho M Bubu, Allal Boutajangout, Ludovic Debure, Alok Vedvyas, Anthony Q Briggs, Mark A Bernard, Joshua L Gills, Elena Valkanova, Alfred Mbah, Mobeena Ghuman, Girardin A Jean‐Louis, Rebecca A Betensky, Karyn Marsh, Henry Rusinek, Ricardo S. Osorio, Thomas Wisniewski, Arjun V. Masurkar (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714842.txt.
Description
Omonigho Bubu and colleagues compared Alzheimer disease biomarkers in cognitively healthy older Black and White adults, asking whether baseline levels differ before any symptoms. Blood tests and brain scans for amyloid and tau are entering care, and cutoffs set in one group may mislead in another. Writing in twenty twenty-five, the team drew on a New York research center cohort. Measures included several plasma proteins tied to amyloid, tau, nerve damage, and brain support cells, plus amyloid and tau brain scans in subsets.
Black participants showed lower levels on most plasma measures and lower amyloid scan signal, with ratios suggesting less amyloid pathology overall. Two measures did not differ between groups. The authors warn that amyloid thresholds may vary by race before symptoms begin, which could affect who qualifies for new therapies and trials. They call for work on social and genetic drivers.
Catalog record
| CREATOR | Omonigho M Bubu, Allal Boutajangout, Ludovic Debure, Alok Vedvyas, Anthony Q Briggs, Mark A Bernard, Joshua L Gills, Elena Valkanova, Alfred Mbah, Mobeena Ghuman, Girardin A Jean‐Louis, Rebecca A Betensky, Karyn Marsh, Henry Rusinek, Ricardo S. Osorio, Thomas Wisniewski, Arjun V. Masurkar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |