Creating Universal Tau PET Scale (Uniτ) Parametric Images – The HEAD Study
Guilherme Povala, Guilherme Bauer‐Negrini, Bruna Bellaver, Firoza Z Lussier, Livia Amaral, Pamela C.L. Ferreira, Quentin Finn, Bruno Zatt, Dana Tudorascu, William J. Jagust, William E Klunk, Val J. Lowe, David N. soleimani‐meigooni, Hwamee Oh, Belen Pascual, Brian A. Gordon, Pedro Rosa‐Neto, Suzanne · 2025
Read Creating Universal Tau PET Scale (Uniτ) Parametric Images – The HEAD Study by Guilherme Povala, Guilherme Bauer‐Negrini, Bruna Bellaver, Firoza Z Lussier, Livia Amaral, Pamela C.L. Ferreira, Quentin Finn, Bruno Zatt, Dana Tudorascu, William J. Jagust, William E Klunk, Val J. Lowe, David N. soleimani‐meigooni, Hwamee Oh, Belen Pascual, Brian A. Gordon, Pedro Rosa‐Neto, Suzanne (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714825.txt.
Description
Guilherme Povala and co-authors work on a common scale for brain scans of tau, in a paper published in 2025. Tau tangles mark Alzheimer's disease, and PET scans can image them, but each tracer dye reads on its own scale. The HEAD study gathers scans from several tracers to set shared anchor values, so results can be compared across clinics and trials.
The team processed scans from 185 people across the aging and Alzheimer's spectrum, taken with two tracers. They aligned image sharpness, picked a reference region, and converted each scan to the shared scale in two steps: anchoring within each tracer, then mapping one tracer onto the other. Values from key brain regions then matched across tracers. A universal scale lets studies pool data that once stayed separate.
Catalog record
| CREATOR | Guilherme Povala, Guilherme Bauer‐Negrini, Bruna Bellaver, Firoza Z Lussier, Livia Amaral, Pamela C.L. Ferreira, Quentin Finn, Bruno Zatt, Dana Tudorascu, William J. Jagust, William E Klunk, Val J. Lowe, David N. soleimani‐meigooni, Hwamee Oh, Belen Pascual, Brian A. Gordon, Pedro Rosa‐Neto, Suzanne |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |