Anesthetic dose‐adjusted intraoperative alpha power in association with biomarkers of preclinical Alzheimer’s disease, preoperative attention function, and postoperative delirium
Melody Reese, Mary Cooter, Kenneth C Roberts, Marty G Woldorff, Jeffrey N Browndyke, Leslie M Shaw, Teresa Waligorska, Henrik Zetterberg, Kaj Blennow, Miles Berger, the MADCO‐PC, INTUIT, and MARBLE Investigators · 2025
Read Anesthetic dose‐adjusted intraoperative alpha power in association with biomarkers of preclinical Alzheimer’s disease, preoperative attention function, and postoperative delirium by Melody Reese, Mary Cooter, Kenneth C Roberts, Marty G Woldorff, Jeffrey N Browndyke, Leslie M Shaw, Teresa Waligorska, Henrik Zetterberg, Kaj Blennow, Miles Berger, the MADCO‐PC, INTUIT, and MARBLE Investigators (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714787.txt.
Description
Melody Reese and co-authors link brain wave patterns under anesthesia to later delirium risk in a 2025 study. Delirium after surgery involves wavering attention and ties to higher Alzheimer risk later. A stronger than usual brain response to anesthetic gas might mark hidden brain weakness before surgery, including early Alzheimer like changes and poor attention.
Eighty two older patients from three surgical cohorts had rich brain recordings during surgery, plus spinal fluid samples and thinking tests before it. The team computed an anesthetic dose adjusted alpha power measure for each patient. They then tested whether that measure tracked with spinal fluid markers, pre surgery attention, and delirium after surgery.
Catalog record
| CREATOR | Melody Reese, Mary Cooter, Kenneth C Roberts, Marty G Woldorff, Jeffrey N Browndyke, Leslie M Shaw, Teresa Waligorska, Henrik Zetterberg, Kaj Blennow, Miles Berger, the MADCO‐PC, INTUIT, and MARBLE Investigators |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |