[18F]SMBT‐1 PET can visualize the spatial distribution of reactive astrogliosis in patients with neurodegenerative dementias
Nobuyuki Okamura, Kotaro Hiraoka, Ryota Kobayashi, Naoki Tomita, Aiko Ishiki, Berihu Mesfin, Yingying Wu, Ryuichi Harada, Asuka Kikuchi, Kazuko Takeda, Akio Kikuchi, Katsutoshi Furukawa, Hiroshi Watabe, Shunji Mugikura, Shinobu Kawakatsu, Kenji Ishii, Takashi Nihashi, Takashi Kato, Shozo Furumoto, M · 2025
Read [18F]SMBT‐1 PET can visualize the spatial distribution of reactive astrogliosis in patients with neurodegenerative dementias by Nobuyuki Okamura, Kotaro Hiraoka, Ryota Kobayashi, Naoki Tomita, Aiko Ishiki, Berihu Mesfin, Yingying Wu, Ryuichi Harada, Asuka Kikuchi, Kazuko Takeda, Akio Kikuchi, Katsutoshi Furukawa, Hiroshi Watabe, Shunji Mugikura, Shinobu Kawakatsu, Kenji Ishii, Takashi Nihashi, Takashi Kato, Shozo Furumoto, M (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714721.txt.
Description
When brain cells are damaged, support cells called astrocytes react and change shape, a process named reactive astrogliosis. Okamura and co-authors test a PET tracer that can picture that reaction in living patients, in a 2025 study. The tracer binds a protein that rises in reactive astrocytes.
The study scanned 85 people: healthy controls, people with mild memory loss, Alzheimer's patients, and patients with frontotemporal degeneration. Each person got a short dynamic scan about an hour after the tracer dose. The team compared signal levels across brain regions between the groups. Mapping where support cells react could help doctors tell dementia types apart and track how each one spreads.
Catalog record
| CREATOR | Nobuyuki Okamura, Kotaro Hiraoka, Ryota Kobayashi, Naoki Tomita, Aiko Ishiki, Berihu Mesfin, Yingying Wu, Ryuichi Harada, Asuka Kikuchi, Kazuko Takeda, Akio Kikuchi, Katsutoshi Furukawa, Hiroshi Watabe, Shunji Mugikura, Shinobu Kawakatsu, Kenji Ishii, Takashi Nihashi, Takashi Kato, Shozo Furumoto, M |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |