Dynamic contrast enhanced MRI reveals impaired blood brain barrier in basal forebrain region in patients with Alzheimers disease: A pilot study
Ondrej Lerch, David Kala, Zuzana Nedelska, Haris Hadzic, Jakub Otahal, Jakub Hort · 2025
Read Dynamic contrast enhanced MRI reveals impaired blood brain barrier in basal forebrain region in patients with Alzheimers disease: A pilot study by Ondrej Lerch, David Kala, Zuzana Nedelska, Haris Hadzic, Jakub Otahal, Jakub Hort (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714703.txt.
Description
Ondrej Lerch and co-authors report, in a 2025 pilot study, signs of a leaky blood-brain barrier in a deep brain region in early Alzheimer's disease. The barrier normally shields the brain from the blood. Its failure may help start the disease. A special MRI method can map where the barrier leaks by tracking a contrast dye. The team scanned twenty-nine people: seventeen with normal thinking and twelve with mild impairment from Alzheimer's.
Leak levels were read in three regions hit early by the disease. The clear gap sat in the basal forebrain, in a nucleus that supplies a key memory chemical. Both its front and back parts leaked more in the impaired group. The hippocampus and a nearby cortical area showed no firm difference. The finding backs the basal forebrain as an early site of barrier breakdown.
Catalog record
| CREATOR | Ondrej Lerch, David Kala, Zuzana Nedelska, Haris Hadzic, Jakub Otahal, Jakub Hort |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |