Plasma Proteomic Determinants of Small Vessel Disease of the Brain: the Multi‐Ethnic Study of Atherosclerosis
Rizwan Kalani, Alison E Fohner, Thomas R. Austin, Sheina Emrani, Paul N. Jensen, Alexis Frazier‐Wood, Alain G. Bertoni, Sanjiv J. Shah, Mohamad Habes, Tanweer Rashid, Sokratis Charisis, Keenan A. Walker, William T Longstreth, David L Tirschwell, Bruce M. Psaty, James Floyd, Usman A Tahir, Robert Edg · 2025
Read Plasma Proteomic Determinants of Small Vessel Disease of the Brain: the Multi‐Ethnic Study of Atherosclerosis by Rizwan Kalani, Alison E Fohner, Thomas R. Austin, Sheina Emrani, Paul N. Jensen, Alexis Frazier‐Wood, Alain G. Bertoni, Sanjiv J. Shah, Mohamad Habes, Tanweer Rashid, Sokratis Charisis, Keenan A. Walker, William T Longstreth, David L Tirschwell, Bruce M. Psaty, James Floyd, Usman A Tahir, Robert Edg (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714699.txt.
Description
Rizwan Kalani and co-authors search blood proteins for fingerprints of the brain's small vessel disease, in a 2025 study. This quiet vessel damage drives stroke and dementia, yet hides until scans reveal it. In the Multi-Ethnic Study of Atherosclerosis, the team measured 2,941 plasma proteins and matched them against MRI measures of white matter health, lesion load, enlarged spaces around vessels, and microbleeds.
Samples drawn in 2016 to 2018 met scans from 2018 to 2019, letting the team link each protein to each imaging trait across a diverse cohort. Any protein that tracks the damage could become a blood test for a disease that now needs a scanner to see.
Catalog record
| CREATOR | Rizwan Kalani, Alison E Fohner, Thomas R. Austin, Sheina Emrani, Paul N. Jensen, Alexis Frazier‐Wood, Alain G. Bertoni, Sanjiv J. Shah, Mohamad Habes, Tanweer Rashid, Sokratis Charisis, Keenan A. Walker, William T Longstreth, David L Tirschwell, Bruce M. Psaty, James Floyd, Usman A Tahir, Robert Edg |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |