Harmonization of amyloid PET radiotracers using ComBat and its influence on detecting treatment effects in a simulated clinical trial
Braden Yang, Tom Earnest, Sayantan Kumar, Brian A Gordon, Aristeidis Sotiras · 2025
Read Harmonization of amyloid PET radiotracers using ComBat and its influence on detecting treatment effects in a simulated clinical trial by Braden Yang, Tom Earnest, Sayantan Kumar, Brian A Gordon, Aristeidis Sotiras (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714665.txt.
Description
Braden Yang and co-authors tested a data fix in 2025 for brain scans that track amyloid, a protein linked to Alzheimer's disease. Scans use one of two tracer drugs, and the two give readings that do not quite match. A trial that mixes tracers may lose power to spot a drug effect. The team asked whether a method called ComBat could align the readings while keeping real brain traits.
They built fake trial data from a large set of real scans of people with amyloid in the brain. They then ran one thousand mock trials. Both ComBat and the standard scale raised power to find a true effect when tracers were mixed. Both also cut false alarms when no effect was built in. Regional readings could be aligned by the new method too.
Catalog record
| CREATOR | Braden Yang, Tom Earnest, Sayantan Kumar, Brian A Gordon, Aristeidis Sotiras |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |