Longitudinal associations of microstructural changes, amyloid, and cognition in preclinical Alzheimer's disease
Patrizia Vannini, Giacomo Bertazzoli, Elena Rodriguez‐Vieitez, Max Ramseyer, Ibai Diez, Jorge Sepulcre, Bernard J Hanseeuw, Cristina Lois, Geoffroy Pierre Gagliardi, Carl‐Fredrik Westin, Keith A Johnson, Reisa A Sperling, Gad A Marshall · 2025
Read Longitudinal associations of microstructural changes, amyloid, and cognition in preclinical Alzheimer's disease by Patrizia Vannini, Giacomo Bertazzoli, Elena Rodriguez‐Vieitez, Max Ramseyer, Ibai Diez, Jorge Sepulcre, Bernard J Hanseeuw, Cristina Lois, Geoffroy Pierre Gagliardi, Carl‐Fredrik Westin, Keith A Johnson, Reisa A Sperling, Gad A Marshall (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714664.txt.
Description
Patrizia Vannini and co-authors report a 2025 study that tracks fine brain change, amyloid, and thinking over time. All of the adults were thinking normally at the start. A scan method can gauge fine injury in the brain's outer layer. The team asked how that gauge and amyloid change together over years. Their group held more than one hundred and fifty older adults from a Harvard aging study.
Scans were done at the start and again after four years, and skill tests went on for close to ten. Both amyloid and the fine injury gauge rose over the four years. A rise in amyloid went with a rise in the gauge in one key area. That link showed only in people who already had high amyloid at the start. The work may help trials pick measures that move with the disease.
Catalog record
| CREATOR | Patrizia Vannini, Giacomo Bertazzoli, Elena Rodriguez‐Vieitez, Max Ramseyer, Ibai Diez, Jorge Sepulcre, Bernard J Hanseeuw, Cristina Lois, Geoffroy Pierre Gagliardi, Carl‐Fredrik Westin, Keith A Johnson, Reisa A Sperling, Gad A Marshall |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |