Genome‐wide association of Tau imaging and plasma biomarkers in adults with Down Syndrome
Kang‐Hsien Fan, Muhammad Muaaz Aslam, Lam‐Ha T Dang, Priyanka Gorijala, Ruyu Shi, Eleanor Feingold, M. Ilyas Kamboh, Joseph H. Lee, Laura Xicota, Ann D Cohen, Benjamin L Handen, Bradley T. Christian, Elizabeth Head, Mark Mapstone, Carlos Cruchaga, Alzheimer’s Biomarker Consortium – Down Syndrome (AB · 2025
Read Genome‐wide association of Tau imaging and plasma biomarkers in adults with Down Syndrome by Kang‐Hsien Fan, Muhammad Muaaz Aslam, Lam‐Ha T Dang, Priyanka Gorijala, Ruyu Shi, Eleanor Feingold, M. Ilyas Kamboh, Joseph H. Lee, Laura Xicota, Ann D Cohen, Benjamin L Handen, Bradley T. Christian, Elizabeth Head, Mark Mapstone, Carlos Cruchaga, Alzheimer’s Biomarker Consortium – Down Syndrome (AB (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714658.txt.
Description
Adults with Down syndrome face a high risk of Alzheimer's disease, so the genes behind its markers in this group matter. Kang-Hsien Fan and co-authors ran a genome-wide search in 2025 across 320 adults of European descent in a Down syndrome biomarker consortium. They linked gene data to brain tau scans and to blood levels of several tau forms.
One well-known risk gene variant showed no tie, while its protective sibling variant came with lower blood tau. Three fresh associations reached genome-wide strength, near genes on chromosomes 11, 21, and 7. Two of those spots have also been tied to tau traits in the general population. The authors present this group as a rich resource for finding genes that steer Alzheimer's markers.
Catalog record
| CREATOR | Kang‐Hsien Fan, Muhammad Muaaz Aslam, Lam‐Ha T Dang, Priyanka Gorijala, Ruyu Shi, Eleanor Feingold, M. Ilyas Kamboh, Joseph H. Lee, Laura Xicota, Ann D Cohen, Benjamin L Handen, Bradley T. Christian, Elizabeth Head, Mark Mapstone, Carlos Cruchaga, Alzheimer’s Biomarker Consortium – Down Syndrome (AB |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |